Forming the exterior end of the infraorbital canal, the infraorbital foramen communicates with the infraorbital groove, the canal's opening on the interior side.
The ramifications of the three principal branches of the trigeminal nerve—at the supraorbital, infraorbital, and mental foramen—are distributed on a vertical line (in anterior view) passing through the middle of the pupil. The infraorbital foramen is used as a pressure point to test the sensitivity of the infraorbital nerve. Palpation of the infraorbital foramen during an extraoral examination or an administration of a local anesthetic agent will cause soreness to the area.